If I can use some common guitar terminology, then Amplitube is more AC-30-like, TH3 is a bit more Fender, while NI Guitar Rig 5 Pro is a bit Marshall-like. The truth is that all those guitar studios sound a bit different from each other, with individual character making one more appropriate for one task and another for some other. Of course all of them, Amplitube, TH3 and Guitar Rig (and there are also few others that could appear in that list), cover the full spectrum of guitar sounds, from distorted metal to the clean Fender-like sound, for all genres and styles. So, saying that one offers more amp models, cabinets or effects, at least among the three prominent guitar studios, is nonsense.

Most of them come in both standalone versions and as plug-in effects to be hosted inside your DAW. There are a few really great guitar studios around all offering copious amp models, cabinets, guitar effects and even a kind of multitrack internal studio where you can record different takes during guitar practice. If Jimi Hendrix were still alive, there’d be no doubt which virtual guitar studio would fit him perfectly: Guitar Rig 5 Pro – great rock sounds, out of this world effects.

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